What Are The Side Effects Of Antihistamines?

Confusion

Certain types of antihistamines are associated with confusion. This side effect is particularly pronounced in individuals over sixty-five years old. In fact, studies show an antihistamine called diphenhydramine may be associated with memory loss and an increased risk of dementia in this patient group. Seniors show reduced alertness, impairments in episodic memory, and diminished performance on memory tasks while taking diphenhydramine. The risk of confusion and memory issues seems to increase even more when antihistamines are used long-term. For example, a study conducted in senior patients at the University of Washington found that using antihistamines for three years increased the risk of developing dementia by fifty-four percent compared to using antihistamines for three months. Women who are sixty years old or older who take diphenhydramine with lorazepam have an elevated risk of confusion as well. Some health organizations suggest seniors avoid antihistamine use due to the strong likelihood of confusion and memory problems, and many doctors choose to prescribe an alternate drug for these patients. Individuals of all ages who experience confusion while taking an antihistamine should let their doctor know right away as it may be necessary to stop taking the medication.

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