Overview Of Trazodone

Potential Medication Interactions

Due to the risk of serotonin syndrome, trazodone should not be taken with monoamine oxidase inhibitors like selegiline. Patients who have been using monoamine oxidase inhibitors will need to wait at least two weeks after stopping this treatment before they can safely begin taking trazodone. Taking trazodone with nonsteroidal anti-inflammatories such as naproxen or ibuprofen could increase the risk of bleeding, and using trazodone with central nervous system depressants could increase the likelihood of experiencing side effects. Combining trazodone with digoxin, St. John's wort, other antidepressants, or phenytoin could cause the patient to have more side effects from these drugs. Phenytoin and carbamazepine can make trazodone less effective, and patients who use these medicines may need to take higher doses of trazodone to counteract this. Medication interactions are also possible between trazodone and tramadol, diuretics, blood thinners, and medications used to treat migraines, anxiety, and mood disorders. Patients should always let their doctor know about all of the medications they use, including prescription medicines, over-the-counter drugs, vitamins, minerals, and herbal supplements.