What Is Omeprazole?

Potential Medication Interactions

Omeprazole reduces the effectiveness of nelfinavir, atazanavir, and rilpivirine, and it should not be taken with any of these medicines. Omeprazole also reduces the effectiveness of clopidogrel, and this could lead to blood clots, so patients who take clopidogrel should not take omeprazole. Individuals who take high doses of voriconazole might need a lower dose of omeprazole to avoid side effects, and omeprazole significantly increases the amounts of warfarin, digoxin, saquinavir, and tacrolimus in the body. Patients may have their doses of these medicines lowered while they are taking omeprazole. Antibiotics such as ampicillin may not be as readily absorbed by the body while patients are taking omeprazole, and omeprazole also interferes with the body's ability to absorb iron-containing products. Patients using erlotinib as part of their cancer treatment should speak to their healthcare team; omeprazole can interfere with the effectiveness of this treatment.

Learn about the commonly prescribed alternatives to omeprazole next.