Key Warning Signs Of Nephronophthisis

Polyuria

Increased urine production or polyuria is a common manifestation in individuals affected by nephronophthisis. The kidneys are responsible for reacting to the concentration of an individual's blood and adjusting the amount of fluid being expelled in the urine to keep a healthy balance. When the blood is too concentrated, the kidneys react by decreasing the amount of fluid being filtered out of the blood into the urine. When the blood is too diluted, the kidneys react by absorbing more fluid to be excreted through the individual's urine. This function is vital to a healthy homeostatic state of the human body, and dangerous complications can occur when the kidneys do not respond appropriately to these conditions. Nephronophthisis patients have poorly functioning kidneys due to the inflammation, scarring, and abnormalities in their ciliary structures. Due to this mechanism, the affected individual experiences polydipsia or excessive thirst. The kidneys cannot concentrate the urine, so more fluid is being expelled in diluted urine. The increase in urination causes the brain to signal more thirst. The patient consumes more fluids in response to the feeling of thirst, the kidneys are again unable to concentrate the urine, and this cycle continuously repeats.

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