Guide To The Causes Of Conn's Syndrome

Genetics

Some cases of Conn's syndrome are the result of genetic mutations inherited from a patient's other biological family members. There are three variations of genetic causes of Conn's syndrome. The first variation occurs due to a gene product that forms when the promoter of the CYP11B1 gene and the coding section of the CYP11B2 gene are abnormally combined. This abnormality causes the body to produce too much aldosterone synthase, resulting in an increased production of aldosterone. The second familial genetic variation that causes Conn's syndrome occurs from a genetic abnormality that has not been pinpointed exactly, but it is thought to occur in band 7p22. The last variation of genetic attribution to this syndrome is the result of genetic inheritance of mutations that occur in the KCNJ5 genes of the segment of DNA responsible for encoding the information on how an individual's potassium channels function. Alternatively, the second variation of familial related causes of Conn's syndrome has been seen to manifest in the forms of adenomas or hyperplasia.