What Causes Focal Segmental Glomerulosclerosis?

Inherited Abnormal Genes

Inherited abnormal genes have been identified as a cause in an especially rare form of glomerulosclerosis known as genetic or familial focal segmental glomerulosclerosis. Doctors normally suspect this type of the disease if a patient has several immediate or extended family members with symptoms of glomerulosclerosis. The condition can also develop in children whose parents are carriers. While the carriers do not have symptoms themselves, each parent (carrier) has an abnormal gene they then pass to their child. Researchers are currently investigating new genes that may play a role in this condition, and doctors can offer genetic testing for concerned patients and their families. Patients who choose to have this testing will often have genetic counseling before and after the test. If familial focal segmental glomerulosclerosis is identified, patients will be offered support services and other resources.

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