Causes And Diagnosis Of Alport Syndrome

Autosomal Recessive Inheritance

When both copies of genes are mutated, an autosomal recessive disorder occurs. In the case of ARAS, both parents pass on a defective gene to their child, and the alpha-3 and alpha-4 genes on chromosome two are defective. Both of the involved parents have only one mutated chromosome, which means they may have no symptoms like blood in the urine. Or affected parents may have some blood in the urine with no disease progression. Also, if both parents have mutated alpha-3 and alpha-4 chains, their children have a twenty-five percent chance of contracting Alport syndrome. Both males and females are affected in a similarly severe manner.

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