What Causes Angiomyolipoma?

Neurofibromatosis

Neurofibromatosis (NF) is an uncommon condition that causes tumors to develop in the nervous system, including the spinal cord, brain, and nerves. The disorder is a group of three conditions: NF1, NF2, and schwannomatosis. NF1 causes symptoms such as tiny bumps within the nerves, freckles on the groin and armpit, brown spots on the skin, and scoliosis. NF2 can cause hearing loss, early cataracts, balance issues, and muscle wasting. Schwannomatosis is a separate form of the disease that leads to cutaneous schwannomas or benign central nervous system tumors.

NF1 is also associated with angiomyolipoma. In some cases, cutaneous angiomyolipoma can be mistaken for a neurofibroma in patients with NF. Both NF and angiomyolipoma are caused by mutations on the TSC1 or TSC2 gene.

Next, find out what rare neurological disorder is related to angiomyolipoma.