What Is Tryptophan?

Medications That Interact With Natural Tryptophan

When individuals are increasing their intake of natural tryptophan, it's important to understand how this amino acid interacts with other medications. Some medication interactions are major enough to be dangerous. Tryptophan increases serotonin levels in the brain, and when combined with antidepressant drugs like SSRIs and MAOIs, there's a chance the brain will be flooded with excess serotonin, causing a life-threatening condition known as serotonin syndrome. Central nervous system depressants like benzodiazepines can also interact dangerously with tryptophan because the combined drugs cause too much sleepiness. Any other medications that affect serotonin levels or the central nervous system should be monitored with caution. Patients should always talk to their doctor about the medications they're taking before they start taking any additional supplements.

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