Warning Signs Of Wilson's Disease To Watch For

Premature Osteoporosis

In some patients, Wilson's disease may cause problems with the bones and joints, including premature osteoporosis and arthritis. These problems may even occur in children with Wilson's disease, and they are considered complications of chronic liver disease. Osteoporosis is a condition in which the bones become weak due to decreased bone density, which can be detected through a bone density scan (a special type of x-ray). This condition increases the risk of fractures, and it may also cause chronic back pain. Treatment for osteoporosis typically involves the use of anti-resorptive and anabolic medications. Anti-resorptive therapies, including estrogen and bisphosphonates, preserve bone density by limiting bone resorption. Anabolic medicines such as full-length parathyroid hormone (PTH1-84) and strontium ranelate work to rebuild bone. Other treatments include denosumab and calcitonin. In addition to osteoporosis, some patients with Wilson's disease may develop outgrowths of bone on the large joints of the body; these are known as osteophytes.

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