Warning Signs Of Amyloidosis

Purpura Around The Eyes

Individuals affected by amyloidosis may present with purpura around the eyes as a manifestation of their disease. Purpura is the medical term used to describe red and purple colored spots that occur on a patient's skin and mucous membranes. Purpura form when tiny blood vessels burst and the blood accumulates under the individual's skin. Between fifteen and twenty percent of amyloidosis patients experience this symptom spontaneously or following minor trauma. Purpura happens due to the weakening of blood vessel walls from amyloid deposits. These deposits cause the competency of the blood vessels to handle challenges involving hydrostatic pressure to become impaired. The bleeding manifestations in affected individuals may also be related to the higher prevalence of abnormal platelet aggregation, dysfibrinogenemia, and blood clotting factor deficiencies of factors X, IX, V, VII, and II. The eyes and other facial regions are the most common regions for amyloidosis purpura to occur due to the elevated concentration of blood vessels and capillaries that supply blood to the area. These purpuric lesions also commonly occur in flexural areas of the eyelids, periorbital region, neck, axillae, and nasolabial folds.

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