How To Treat Kallmann Syndrome

Medication To Improve Bone Health

Medication to improve bone health may need to be used in individuals with Kallmann syndrome. Kallmann syndrome patients are at a higher risk of developing osteoporosis than healthy individuals of the same age. Osteoporosis is a condition in which an individual develops brittle and weak bones due to the breakdown of more bone than the amount being regenerated. Bones grow significantly during an individual's childhood and go through a stage of calcification and strengthening during puberty. Estrogen in females and testosterone in males are hormones that play key roles in this process. Kallmann syndrome, we know, is characterized by an individual who does not experience the onset of puberty and all of the processes that come with it, including this phase of bone calcification and strengthening. Hormone replacement therapy can improve circumstances to a certain degree, but most patients continue to have problems with bone density throughout their life. A range of medications can be used to help maintain or increase bone density in Kallmann syndrome patients, including alendronate, risedronate, ibandronate, and zoledronic acid.

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