Symptoms Of Selective IgA Deficiency And Related Conditions

Sinusitis

Patients who experience recurrent sinusitis infections may have selective IgA deficiency. The sinuses are air pockets that sit just within the bones of an individual's face that surround their nose. Typically, these pockets are hollow and function to produce mucus that subsequently drains into the nose. However, the sinuses can easily become blocked, which makes a nice place for pathogens to colonize. The immune system responds to this pathogenic invasion, and the result is sinusitis. The blockage that begins the cascade of events leading to sinusitis can be caused by allergies. The mucus that lines the nasal passages and sinuses does not contain immunoglobulin A in individuals who have selective IgA deficiency. This malfunction means their natural defenses to a pathogenic invasion of these areas are impaired. Often times, sinusitis can be challenging to treat in selective IgA deficiency patients because topical intranasal beclomethasone, antibiotics, and N -acetylcysteine are ineffective at reducing sinus inflammation and eradicating pathogens.

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