Serious Symptoms Of Chronic Inflammatory Demyelinating Polyneuropathy (CIDP)

Numbness And Tingling

The immune system in chronic inflammatory demyelinating polyneuropathy patients may attack the large-diameter sensory nerve fibers since they tend to be the most heavily myelinated. The sensory nerves are responsible for communicating information about pain and temperature to an individual's brain. When the myelin sheath around the sensory nerves is eaten away by the inappropriate autoimmunity of the immune system, the nerves become more susceptible to damage and dysfunction. Nerve impulses do not conduct from one nerve to the next very well without their insulating and protective myelin sheathing. Nerves damaged past their sheathing layer may only transmit partial impulses or may not transmit impulses at all. When no impulses are sent to the brain upon painful stimuli, it is described as numbness. Nerves that send partial or disrupted impulses to the brain upon pain and or temperature stimuli tend to produce a sensation that can be described as tingling.

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