Causes Of Progressive Bulbar Palsy

Genetic Link

There are few study findings regarding a genetic link as the cause of progressive bulbar palsy. One study found the development of this disease was consistent with a mutation to the SOD1 gene located on chromosome 21. SOD1 produces an enzyme responsible for attaching copper and zinc and eliminating free radicals in the body. Patients with this mutation were more likely to develop amyotrophic lateral sclerosis as well. There is a likelihood the mutations happen in an autosomal recessive pattern. It is not on one of the sex chromosomes and must have two copies to show a mutation.