Guide To The Symptoms And Treatment Of Uncombable Hair Syndrome

Uncombable hair syndrome is a rare genetic condition that affects the hair shaft. The syndrome most often develops within the first three years of life, and it has been diagnosed as late as twelve years old. While most cases of uncombable hair syndrome are not associated with any underlying medical conditions, some patients with the disorder may also have ectodermal dysplasias, Bork syndrome, or Angel-shaped phalangoepiphyseal dysplasia. Currently, scientists have identified genetic mutations on the PADI3, TGM3, and TCHH genes are involved in this disease. To diagnose uncombable hair syndrome, a dermatologist will observe the patient's hair and examine the hair shaft under an electron microscope. Typically, the syndrome improves with time, and patients diagnosed in early childhood often have hair that lies flat and is of a nearly normal texture by the time they are adolescents.

The guide below outlines some of the most common symptoms and treatments associated with uncombable hair syndrome.

Disorderly Light Colored Hair

Disorderly, light-colored hair is one of the most frequent symptoms of uncombable hair syndrome. Patients generally have blonde, straw-colored, white, or silvery hair with a shiny, glistening appearance. When examined under a microscope, the individual hair strands of patients with uncombable hair syndrome are triangular or kidney-shaped, and there is a longitudinal groove on one or two of the sides of a strand. As the patient ages, their hair color may become increasingly blonde or silvery. The hair growth rate is either normal or only slightly slower than normal, and patients have a normal amount of scalp hair. Although the hair may be dry or coarse, it is not considered brittle or fragile. In some patients, the hair can also appear to be kinked.

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