Guide To The Causes And Treatments For Isaac's Syndrome

Hereditary Connection

There is a hereditary connection with some presentations of Isaacs' syndrome. In these cases, rather than being acquired at some point in life, the condition is caused by genetics. Genes are passed from parent to child. If a patient has a family history of Isaacs' syndrome, they have a larger chance of developing the disease. Hereditary Isaacs' syndrome is significantly rarer than the acquired form of the disease. When families have shown a history of Isaacs' syndrome, there tends to be a mutation of the KCNA1 gene. However, there hasn't been conclusive research proving which genes are affected, thus it's possible additional genes play a part in the development of Isaacs' syndrome. The KCNA1 gene is part of a larger gene family that instructs the body on how to make potassium channels. The channels transport potassium out of and into the cells, helping a cell transmit and generate electrical signals. With acquired Isaacs' syndrome, the immune system attacks and destroys potassium channels. However, in hereditary Isaacs' syndrome, it's possible the KCNA1 gene's mutation causes the body to make an inadequate number of potassium channels.

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