Causes And Risk Factors Of Aarskog Syndrome

X-Linked Recessive Pattern

Aarskog syndrome is passed down through an X-linked recessive pattern, which means the mutations occur in genes on the X chromosome. One characteristic of this type of inheritance is fathers cannot pass X-linked characteristics and traits to their sons, meaning there is no male-to-male transmission of Aarskog. It is either passed from a mother to children of both genders or from a father to a daughter, though this is much rarer. As males only possess one X chromosome, only a single copy of the genetic mutation in each cell is required for the boy to develop the condition. In girls, however, a mutation would need to affect both copies of the gene for the disorder to present with the same magnitude. It is highly unlikely for females to be born with two altered copies of the FGD1 gene.

Keep going to learn more about the risk factors and causes of this condition.