Causes, Risk Factors, And Complications Of Primary Biliary Cholangitis

Genetics And Family History

Though no defective gene mutation has been found to correlate with primary biliary cholangitis, it is more likely to occur in those with similar genetics and family history. If a sibling has been affected by primary biliary cholangitis, it is very common for another sibling to acquire it. If one identical twin has this condition, the other twin is extremely likely to have it as well. This correlation is not as strong with fraternal twins and regular siblings. Without definitive evidence of hereditary causes, scientists believe primary biliary cholangitis could be caused by a combination of genetics, epigenetics, and environmental factors. Epigenetics includes mutations that may happen on a molecular level without noticeably altering DNA.

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