Causes Of Cushing's Syndrome

Inherited Connection

The majority of Cushing's cases occur in patients with no family history of the disease. However, recent research suggests that there may be an inherited connection involved in some instances of Cushing's syndrome. Specifically, scientists noted that a mutation in the CABLES1 gene might contribute to the disease. German researchers have also identified that mutations of the PRKACA gene are involved in the adrenal tumors that can occur with Cushing's. Some diseases that lead to Cushing's may themselves have components that can be inherited. Some of the genetic mutations associated with Cushing's syndrome may not be passed down through families. Rather, they may be sporadic or random, induced during a person's life by environmental or other factors that resulted in damaged DNA.

Next, uncover the rare cause of Cushing's syndrome and how it happens.