What Are The Causes, Complications, And Symptoms Of Gilbert Syndrome?

Gilbert syndrome is a genetic disorder that causes the liver to improperly process bilirubin, which is produced when red blood cells break down. Ordinarily, the liver converts it to a form that can be removed from the body. When this process doesn't occur, bilirubin may build up in toxic levels in the blood. Gilbert syndrome is a fairly common genetic disorder, affecting between three and seven percent of individuals residing in the United States. It's more commonly found in men than women. The disorder is usually mild and may not present with any symptoms. However, Gilbert syndrome patients may be predisposed to harmful buildups of bilirubin if they have other risk factors, which include general illness, menstruation, skipping meals or fasting, or exercising excessively.

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Gene Mutation

Gilbert syndrome is caused by a gene mutation or mutations in the UGT1A1 gene. This is the gene that gives the body instructions for how to make the enzyme bilirubin-UGT, a necessary component for bilirubin removal. Bilirubin-UGT is typically found in an individual's liver cells. The enzyme causes chemical reactions called glucuronidations. Throughout these reactions, glucuronic acid is transferred into unconjugated bilirubin. Unconjugated bilirubin is the type that cannot be removed from the blood. After glucuronic acid combines with the bilirubin, it becomes conjugated. The glucuronidation process allows bilirubin to dissolve in water and exit the body. The most common Gilbert syndrome gene mutation is called UGT1A1*28. It occurs close to the 'promoter region' of the gene, the portion responsible for producing bilirubin-UGT. The change impairs the production of the enzyme but does not inhibit it entirely. A Gilbert syndrome patient produces about thirty percent of an average individual's bilirubin-UGT, which causes unconjugated bilirubin to be processed much more slowly, leading to bilirubin buildups in the blood.

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