Causes And Complications Linked To DiGeorge Syndrome

Increased Risk Of Autoimmune Disorders

Individuals with DiGeorge syndrome might have a higher risk of developing autoimmune disorders, particularly in cases where the immune system had poor functioning during childhood. Poor immune function tends to be related to problems with the thymus gland. This gland is found under the breastbone. It's the place a certain kind of white blood cell called the T-cell matures. In DiGeorge syndrome patients, there may be a missing thymus gland or underdeveloped thymus gland. This causes an insufficient number of T-cells to mature. Since these cells are necessary to fight infections, children have an impaired immune system and may experience frequent and severe infections. As they get older, this compromised immune function increases the chances of developing Graves' disease, rheumatoid arthritis, or other conditions where the immune system mistakenly attacks the body.