What Increases The Risk Of Eye Melanoma?

Dysplastic Nevus Syndrome

Dysplastic nevus syndrome is a skin condition that manifests itself through the presence of a large number of atypical moles around the body. When dysplastic nevus syndrome is inherited, it is most likely a result of DNA mutations in the CDKN2A gene. The excessive irregular moles that occur in dysplastic nevua syndrome patients are caused by overstimulation of the system of cells that create melanin or the melanocytic system. However, this overstimulation is not isolated to just the skin tissues. This also occurs in the colored region of the eye. The overstimulation causes an increased incidence of localized spots of melanocytic proliferation or melanocyte overgrowth in the eye. This overgrowth is what is responsible for discolorations or spots in the colored region of the eye. Because eye melanoma often originates from eye spots and discolorations, individuals with dysplastic nevus syndrome are at a higher risk for developing it.

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