What Increases The Risk Of Chondrosarcoma?

Maffucci Syndrome

Maffucci syndrome is a disorder where multiple benign or noncancerous cartilage growths develop inside of the bones, and purplish or red growths develop in the skin. Much like Ollier disease, Maffucci syndrome is caused by a gene mutation, and individuals affected by it are at a higher risk of developing chondrosarcoma. Maffucci syndrome enchondromas develop near the part of the bones where growth typically occurs. Benign tumors usually stop becoming larger when the individual with Maffucci syndrome stops growing. While it sounds similar to Ollier disease, Maffucci syndrome has two distinct elements that do not occur in Ollier disease patients. Hemangiomas are skin growths containing tangles of irregular blood vessels that also happen in individuals affected by Maffucci syndrome. In addition, masses that contain tangles of the thin tubes where lymph fluid travels or lymphangiomas develop in Mafucci syndrome patients. Both hemangiomas and lymphangiomas can grow anywhere on the body. Additional mutations that occur alongside the Maffucci syndrome mutation are responsible for some of the enchondromas becoming malignant, resulting in chondrosarcoma.

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