Guide To Bone Cancer Causes And Risk Factors

Li-Fraumeni Syndrome

A Li-Fraumeni syndrome patient is at a greater risk of developing cancer in their bone tissues than an individual who is not affected by the syndrome. Li-Fraumeni syndrome is a hereditary disorder characterized by a mutation in an individual's TP53 tumor suppressor gene. This mutation causes the body to have an impaired ability to prevent malignancy from forming in the tissues throughout the body. However, bone cancer is only one of the common types of cancer known to develop in individuals affected by Li-Fraumeni syndrome. Aside from osteosarcoma, soft tissue sarcoma, breast cancer, acute leukemia, adrenocortical carcinoma, brain cancer, and central nervous system tumors are also known to occur. There are no symptoms that occur in Li-Fraumeni syndrome patients aside from the development of cancer. Patients diagnosed with this syndrome are advised to take precautions to ensure early detection in case osteosarcoma or another form of cancer develops in their body.