Most Common Types Of Cancer Found In Li-Fraumeni Syndrome

Breast Cancer

Breast cancer is a form of cancer that develops in the cells that make up the tissues of the breasts. The breasts contain thousands of lobules, fat, and connective tissues. The most common place for breast cancer to develop is in the inner lining of the lobules and milk ducts. A new area of thickened tissue or a lump in the armpit or breast is often the first symptom to indicate breast cancer. Other symptoms include pain in the breast or armpit, breast skin redness, pitting of the breast skin, rash around the nipple, breast discharge, changes in breast size, and changes in breast shape. Breast cancer can metastasize to other tissues throughout the body and is staged depending on the degree of metastasis. A breast exam, tissue biopsy, ultrasound, MRI, or mammogram may be used to diagnose an individual's Li-Fraumeni precipitated breast cancer. Treatment consists of surgery, chemotherapy, hormone therapy, targeted therapy, and radiation therapy. Li-Fraumeni syndrome patients may need to undergo more frequent mammogram to help with early detection.