Guide To The Causes And Risk Factors For Rhabdomyosarcoma

Li-Fraumeni Syndrome

Li-Fraumeni syndrome can cause patients to be at a higher risk of developing rhabdomyosarcoma than healthy individuals. Li-Fraumeni syndrome is a rare genetic disorder where certain gene patterns and alterations cause the individual to be at a very high risk of developing some forms of cancer during their childhood and young adult years. The most common types of cancers that occur in Li-Fraumeni syndrome patients include soft tissue sarcomas, osteosarcoma, brain tumors, adrenocortical carcinoma, leukemias, and breast cancer. Li-Fraumeni syndrome is caused by mutations in the TP53 and CHEK2 genes. TP53 is a gene that is a part of a group of genes responsible for controlling the division and growth of cells around the body. A problem with the TP53 gene gives cancerous cells a better opportunity to multiply. The CHEK2 gene is also included in the tumor suppressor gene group, making the patient susceptible to cancer growth like rhabdomyosarcoma through the same mechanism.

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