Treatment Options For Thalassemia

Thalassemia is an inherited blood disorder common in Asia, Africa, and the Mediterranean. This condition occurs when there are fewer red blood cells and hemoglobin (what allows the red blood cells to carry oxygen) in an individual's body than what is considered normal. The genetic abnormality that causes thalassemia is due to two genes and results in a deficiency of beta globulins, an essential part of the hemoglobin molecule, which transports oxygen. This culminates in markedly reduced or no hemoglobin in the red blood cells.

Thalassemia minor is usually mild anemia with up to a fifty percent reduction in hemoglobin. Individuals in this state are generally able to lead fairly normal lives. In fact, this carrier state protects the patient from malaria, which is endemic in those areas of the world. Thalassemia major results in severe anemia, which must be treated. A child with symptomatic beta-thalassemia is pale, sometimes jaundiced, with deformed, often decayed teeth, and a bumpy skull. The spleen and liver will often be enlarged, and the patient may also be in heart failure. Without treatment, most children with this condition will not live past their teenage years, which is why treatment is crucial.

With all of this in mind, get to know the major approaches to treating thalassemia now.

Observational Approach

Neonatal screening, especially in high-risk populations, targets the children who need to be watched. Some states do not require screening for hemoglobinopathies, and immigrant children may be missed as well. An observational approach will be taken with identified children, sometimes for years. Observation is usually the first line of treatment for an individual with a minor case of thalassemia.

During this time, a patient's growth and development, glucose and thyroid metabolism, iron levels, and potential dental problems will be monitored. The chronic anemia causes short stature and delay of puberty. Iron overload is a major problem and can affect the development of the thyroid and pancreas. Other major concerns during this time are the onset of pulmonary hypertension, heart failure, and osteoporosis. Cardiac evaluation with an MRI is recommended every year, starting eight or nine years old. Supplementing with folic acid is recommended.

Learn how to effectively treat thalassemia with food now.