Risk Factors And Causes Of Pernicious Anemia

Family History Of The Condition

Over the years, scientific research has identified evidence that there is a genetic factor that causes a determined predisposition to pernicious anemia. Research suggests the production of the parietal cell antibody is influenced by a dominant autosomal gene, which enables a family history of the condition. While the exact mechanism of such genetic factor and its occurrence is not clear at this time, there are other indirect ways pernicious anemia can be caused by genetics. Numerous other autoimmune disorders have a tendency to run in families, and some of these disorders increase the risk of pernicious anemia or even directly cause its development. Furthermore, it is plausible to link a hyperactive immune response to genetics because of the complicated processes that occur in evolution and natural selection. It is said increased immunity is a naturally selective genetic result of generational exposure to certain types of diseases. This happens because the human body adapts and creates immunity to different things from generation to generation, and that compounded increased immunity may express in the form of an autoimmune disorder like pernicious anemia.